A model for discrete spindle elongation
نویسندگان
چکیده
منابع مشابه
A theoretical model of mitotic spindle elongation under experimental constraints
During the division of eukaryotic cells, the duplicated set of chromosomes is separated by the mitotic spindle, a large multicomponent assembly consisting of several hundred proteins in human cells (Sauer et al, 2005). Researchers have started to move from putting together the parts list of spindle components and from generating an atlas of their localizations toward trying to understand at a s...
متن کاملPhosphorylation State Defines Discrete Roles for Monopolin in Chromosome Attachment and Spindle Elongation
BACKGROUND It is unknown how oscillations in Cdk1 activity drive the dramatic changes in chromosome and spindle dynamics that occur at the metaphase/anaphase transition. RESULTS We show that the Schizosaccharomyces pombe monopolin complex has distinct functions in metaphase and anaphase that are determined by the phosphorylation state of its Mde4 subunit. When Cdk1 activity is high in metapha...
متن کاملinvestigating the feasibility of a proposed model for geometric design of deployable arch structures
deployable scissor type structures are composed of the so-called scissor-like elements (sles), which are connected to each other at an intermediate point through a pivotal connection and allow them to be folded into a compact bundle for storage or transport. several sles are connected to each other in order to form units with regular polygonal plan views. the sides and radii of the polygons are...
Stu2 Promotes Mitotic Spindle Elongation in Anaphase
During anaphase, mitotic spindles elongate up to five times their metaphase length. This process, known as anaphase B, is essential for correct segregation of chromosomes. Here, we examine the control of spindle length during anaphase in the budding yeast Saccharomyces cerevisiae. We show that microtubule stabilization during anaphase requires the microtubule-associated protein Stu2. We further...
متن کاملInterzonal microtubules are dynamic during spindle elongation.
The pattern and extent of microtubule assembly during spindle elongation has been examined in PtK1 cells by microinjection of biotin-tubulin and immunolocalization of biotin-tubulin-containing microtubules using antibodies to biotin. PtK1 cells were microinjected at 30 degrees C, incubated for various intervals to allow incorporation of biotin-tubulin into microtubules, then lysed, fixed and st...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.3.14760